The importance of minipigs in dermal safety assessment: an overview. (3rd April 2017)

• Record Type: Journal Article
• Authors: Stricker-Krongrad, Alain; Shoemake, Catherine R.; Liu, Jason; Brocksmith, Derek; Bouchard, Guy
• Is Part Of: Cutaneous and ocular toxicology. Volume 36:Number 2(2017)
• Page Start: 105
• Page End: 113
• Publication Date: 2017-04-03
• Subjects: Dermal drug safety -- dermal pharmacology -- dermal toxicology; Dermatotoxicology -- Periodicals; Ocular toxicology -- Periodicals; Ocular pharmacology -- Periodicals; Dermatopharmacology -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1080/15569527.2016.1178277
• Languages: English
• ISSNs: 1556-9527

Abstract

Abstract: The use of miniature swine as a non-rodent species in safety assessment has continued to expand for over a decade and their use has become routine, particularly in pharmacology as a model for human integumentary diseases. Translational preclinical swine study data are now favorably compared and contrasted to human data, and miniature swine models provide important information in dermal safety assessment and skin pharmacology. For example, the miniature swine model has been well-accepted for cutaneous absorption and toxicity studies due to swine integument being morphologically and functionally similar to human skin. Subsequently, this model is important to dermal drug development programs, and it is the animal model of choice for assessment of dermal absorption, local tolerance and systemic toxicity following dermal exposures. In conclusion, the miniature swine model has an important role to play in the safety assessment of pharmaceutical products and in multiple aspects of human dermal drug development.