A Young Woman with Recurrent Kidney Stones: Questions on Hypokalaemic Tubular Acidosis. Issue 1 (2017)

• Record Type: Journal Article
• Authors: Vanmassenhove, Jill; Lameire, Norbert
• Is Part Of: Nephrology @ point of care. Volume 3:Issue 1(2017)
• Publication Date: 2017
• Subjects: Kidney stones -- Metabolic hypokalaemic tubular acidosis -- Recurrent nephrolithiasis; Nephrology -- Periodicals; 616.61
• DOI: 10.5301/napoc.5000209
• Languages: English
• ISSNs: 2059-3007

Abstract

This paper discusses the diagnostic and therapeutic approach to the problem of a young woman presenting with recurrent kidney stones. In the clinical work-up, a hypokalaemic normal anion gap metabolic acidosis was found. The diagnostic tests to solve this common clinical problem and some therapeutic recommendations are discussed. Question on hypokalaemic tubular acidosis: 1. What is the significance of the plasma anion gap (PAG)? 2. How does one appreciate the respiratory component of the acid base status? 3. How does one perform tests for tubular acidification disturbances? 4. What is the pathogenesis of distal tubular acidification disturbances? 5. What is the explanation of the hypokalaemia in distal tubular acidosis? 6. What is the pathogenesis of nephrolithiasis in distal tubular acidosis? 7. How does one treat a patient with distal tubular acidosis and recurrent nephrolithiasis?