Demystifying the Monoclonal Gammopathies of Renal Significance. Issue 3 (November 2017)

• Record Type: Journal Article
• Authors: Hogan, Jonathan J.
• Is Part Of: Journal of onco-nephrology. Volume 1:Issue 3(2017)
• Page Start: 156
• Page End: 162
• Publication Date: 2017-11
• Subjects: Glomerulonephritis -- Lymphoma -- Monoclonal gammopathy -- Myeloma -- Paraprotein; Nephrology -- Periodicals; Kidneys -- Cancer -- Periodicals; Kidneys -- Tumors -- Periodicals; 616.61
• DOI: 10.5301/jo-n.5000032
• Languages: English
• ISSNs: 2399-3693

Abstract

The monoclonal gammopathies of renal significance (MGRS) are paraprotein-mediated diseases of the kidney in patients who do not meet criteria for multiple myeloma or systemic lymphoma. The diagnosis requires a kidney biopsy, and management is geared toward detection and treatment of the underlying plasma or B cell clone that is producing the pathogenic paraprotein. This approach is extrapolated from well-studied paraprotein-mediated diseases such as multiple myeloma and AL amyloidosis. In this review, we aim to demystify the workup and treatment of the MGRS disorders.