Ipsilateral cortical motor desynchronisation is reduced in Benign Epilepsy with Centro-Temporal Spikes. Issue 2 (February 2016)

• Record Type: Journal Article
• Authors: Brindley, Lisa M.; Koelewijn, Loes; Kirby, Amanda; Williams, Natalie; Thomas, Marie; te Water-Naudé, Johann; Gibbon, Frances; Muthukumaraswamy, Suresh; Singh, Krish D.; Hamandi, Khalid
• Is Part Of: Clinical neurophysiology. Volume 127:Issue 2(2016:Feb.)
• Page Start: 1147
• Page End: 1156
• Publication Date: 2016-02
• Subjects: Development -- BECTS -- MEG -- Movement -- Oscillations; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2015.08.020
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: On a MEG motor task in children with Benign Epilepsy with Centro-Temporal Spikes (BECTS) we found reduced ipsilateral cortical desynchronisation. This reduced ipsilateral cortical desynchronisation was linked to poorer motor skills and more recent seizures. Our findings suggest disrupted inter-hemispheric interactions during motor control in BECTS. Abstract: Objective: Magnetoencephalography (MEG) and a simple motor paradigm were used to study induced sensorimotor responses and their relationship to motor skills in children diagnosed with Benign Epilepsy with Centro-Temporal Spikes (BECTS). Methods: Twenty-one children with BECTS and 15 age-matched controls completed a finger abduction task in MEG; movement-related oscillatory responses were derived and contrasted between groups. A subset of children also completed psycho-behavioural assessments. Regression analyses explored the relationship of MEG responses to manual dexterity performance, and dependence upon clinical characteristics. Results: In children with BECTS, manual dexterity was below the population mean ( p = .002) and three showed severe impairment. Our main significant finding was of reduced ipsilateral movement related beta desynchrony (MRBDi) in BECTS relative to the control group ( p = .03) and predicted by epileptic seizure recency ( p = .02), but not age, medication status, or duration of epilepsy. Laterality scores across the entire cohort indicated that less lateralised MRBD predicted better manual dexterity ( p = .04). Conclusions: Altered movement-related oscillatory responses in ipsilateral motor cortex were associated with motor skill deficits in children with BECTS. These changes were more marked in those with more recent seizures. Significance: These findings may reflect differences in inter-hemispheric interactions during motor control in BECTS.