Serial peripheral nerve ultrasound in Guillain–Barré syndrome. Issue 2 (February 2016)

• Record Type: Journal Article
• Authors: Razali, Siti Nur Omaira; Arumugam, Thaarani; Yuki, Nobuhiro; Rozalli, Faizatul Izza; Goh, Khean-Jin; Shahrizaila, Nortina
• Is Part Of: Clinical neurophysiology. Volume 127:Issue 2(2016:Feb.)
• Page Start: 1652
• Page End: 1656
• Publication Date: 2016-02
• Subjects: Guillain–Barré syndrome -- EMG -- Anti-ganglioside antibody -- Nerve conduction study -- Nerve ultrasound; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2015.06.030
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Serial nerve ultrasound studies demonstrate gradual improvement in nerve cross-sectional area in Guillain–Barré syndrome. The changes become significant after 12 weeks of disease onset when patients are in the recovery phase. In the acute phase, nerve ultrasound may not be able to differentiate between axonal and demyelinating subtypes based on nerve cross-sectional areas. Abstract: Objective: To assess the longitudinal changes of nerve ultrasound in Guillain–Barré syndrome (GBS) patients. Methods: We prospectively recruited 17 GBS patients and 17 age and gender-matched controls. Serial studies of their nerve conduction parameters and nerve ultrasound, documenting the cross-sectional areas (CSA), were performed at admission and repeated at several time points throughout disease course. Results: Serial nerve ultrasound revealed significantly enlarged CSA in median, ulnar and sural nerves within the first 3 weeks of disease onset. Longitudinal evaluation revealed an improvement in the nerve CSA with time, reaching significance in the ulnar and sural nerves after 12 weeks. There was no significant difference between the demyelinating and axonal subtypes. There was also no significant correlation found between nerve CSA and neurophysiological parameters or changes in nerve CSA and muscle strength. Conclusion: In GBS, serial studies of peripheral nerve ultrasound CSA are helpful to detect a gradual improvement in the nerve size. Significance: Serial nerve ultrasound studies could serve as a useful tool in demonstrating nerve recovery in GBS.