Risk of angioedema associated with levetiracetam compared with phenytoin: Findings of the observational health data sciences and informatics research network. (6th July 2017)

• Record Type: Journal Article
• Authors: Duke, Jon D.; Ryan, Patrick B.; Suchard, Marc A.; Hripcsak, George; Jin, Peng; Reich, Christian; Schwalm, Marie‐Sophie; Khoma, Yuriy; Wu, Yonghui; Xu, Hua; Shah, Nigam H.; Banda, Juan M.; Schuemie, Martijn J.
• Is Part Of: Epilepsia. Volume 58:issue 8(2017)
• Page Start: e101
• Page End: e106
• Publication Date: 2017-07-06
• Subjects: Angioedema -- Levetiracetam -- Anticonvulsant hypersensitivity syndrome -- Pharmacovigilance -- Observational research -- Adverse drug reactions; Epilepsy -- Periodicals; 616.853
• DOI: 10.1111/epi.13828
• Languages: English
• ISSNs: 0013-9580

Abstract

Summary: Recent adverse event reports have raised the question of increased angioedema risk associated with exposure to levetiracetam. To help address this question, the Observational Health Data Sciences and Informatics research network conducted a retrospective observational new‐user cohort study of seizure patients exposed to levetiracetam (n = 276, 665) across 10 databases. With phenytoin users (n = 74, 682) as a comparator group, propensity score‐matching was conducted and hazard ratios computed for angioedema events by per‐protocol and intent‐to‐treat analyses. Angioedema events were rare in both the levetiracetam and phenytoin groups (54 vs. 71 in per‐protocol and 248 vs. 435 in intent‐to‐treat). No significant increase in angioedema risk with levetiracetam was seen in any individual database (hazard ratios ranging from 0.43 to 1.31). Meta‐analysis showed a summary hazard ratio of 0.72 (95% confidence interval [CI] 0.39–1.31) and 0.64 (95% CI 0.52–0.79) for the per‐protocol and intent‐to‐treat analyses, respectively. The results suggest that levetiracetam has the same or lower risk for angioedema than phenytoin, which does not currently carry a labeled warning for angioedema. Further studies are warranted to evaluate angioedema risk across all antiepileptic drugs.