A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents. Issue 6 (December 2015)

• Record Type: Journal Article
• Authors: Carpenter, Chelsea; Sidney, John; Kolla, Ravi; Nayak, Kaustuv; Tomiyama, Helena; Tomiyama, Claudia; Padilla, Oscar A.; Rozot, Virginie; Ahamed, Syed F.; Ponte, Carlos; Rolla, Valeria; Antas, Paulo R.; Chandele, Anmol; Kenneth, John; Laxmi, Seetha; Makgotlho, Edward; Vanini, Valentina; Ippolito, Giuseppe; Kazanova, Alexandra S.; Panteleev, Alexander V.; Hanekom, Willem; Mayanja-Kizza, Harriet; Lewinsohn, David; Saito, Mayuko; McElrath, M. Juliana; Boom, W. Henry; Goletti, Delia; Gilman, Robert; Lyadova, Irina V.; Scriba, Thomas J.; Kallas, Esper G.; Murali-Krishna, Kaja; Sette, Alessandro; Lindestam Arlehamn, Cecilia S.;
• Is Part Of: Tuberculosis. Volume 95:Issue 6(2015)
• Page Start: 713
• Page End: 721
• Publication Date: 2015-12
• Subjects: Tuberculosis -- T cell antigen -- Vaccine -- CD4 -- LTBI -- BCG; MTB Mycobacterium tuberculosis -- LTBI latent tuberculosis infection -- BCG bacillus Calmette-Guérin -- TB tuberculosis -- IGRA interferon gamma release assay -- TST tuberculin skin test -- SFC spot-forming cells -- NTM non-tuberculous mycobacteria; 616.995
• DOI: 10.1016/j.tube.2015.07.001
• Languages: English
• ISSNs: 1472-9792

Abstract

Summary: We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis (MTB) antigens in individuals latently infected with MTB (LTBI), and uninfected individuals with previous BCG vaccination, from nine locations and populations with different HLA distribution, MTB exposure rates, and standards of TB care. This comparison revealed similar response magnitudes in diverse LTBI and BCG-vaccinated cohorts and significant correlation between responses in LTBIs from the USA and other locations. Many antigens were uniformly recognized, suggesting suitability for inclusion in vaccines targeting diverse populations. Several antigens were similarly immunodominant in LTBI and BCG cohorts, suggesting applicability for vaccines aimed at boosting BCG responses. The panel of MTB antigens will be valuable for characterizing MTB-specific CD4 T cell responses irrespective of ethnicity, infecting MTB strains and BCG vaccination status. Our results illustrate how a comparative analysis can provide insight into the relative immunogenicity of existing and novel vaccine candidates in LTBIs.