Coupling Microreaction Technologies, Polymer Chemistry, and Processing to Produce Polymeric Micro and Nanoparticles with Controlled Size, Morphology, and Composition. Issue 9 (9th July 2013)

• Record Type: Journal Article
• Authors: Serra, Christophe A.; Cortese, Bruno; Khan, Ikram Ullah; Anton, Nicolas; de Croon, Mart H. J. M.; Hessel, Volker; Ono, Tsutomu; Vandamme, Thierry
• Is Part Of: Macromolecular reaction engineering. Volume 7:Issue 9(2013:Sep.)
• Page Start: 414
• Page End: 439
• Publication Date: 2013-07-09
• Subjects: microfluidics -- microreactors -- polymers -- microparticles -- nanoparticles -- drug delivery; Polymers -- Periodicals; Polymerization -- Periodicals; Reaction mechanisms (Chemistry) -- Periodicals; Electronic journals; 547.705
• DOI: 10.1002/mren.201300101
• Languages: English
• ISSNs: 1862-832X

Abstract

Abstract: Polymeric micro‐ and nanoparticles receive the attention of researchers in different areas such as drug delivery, sensing, imaging, cosmetics, diagnostics, and biotechnology. However, processes with conventional equipment do not always allow precise control of their morphology, size, size distribution, and composition. On the other hand, microreaction technology offers improved control over the hydrodynamics, mass and heat transfer, allowing production of polymeric particles with better defined or new characteristics. Thus new horizons in polymer particle engineering arise from the use of microstructured or microfluidic devices. This article gives an insight into the latest developments and trends in the production of polymeric micro‐ and nanoparticles realized by microreaction technology directly. Abstract : A hydrodynamic flow‐focusing microfluidic device, coupled to a Tesla micromixer, enables rapid mixing and precipitation to form lipid–polymer nanoparticles. These nanoparticles have a PLGA hydrophobic core for drug encapsulation and a PEG hydrophilic shell with a lecithin layer in between. In the same way, lipid quantum dot nanoparticles can be formed with a core–shell structure.