Test–retest reliability of fMRI activation generated by different saccade tasks. Issue 1 (4th November 2013)

• Record Type: Journal Article
• Authors: Lukasova, Katerina; Sommer, Jens; Nucci‐da‐Silva, Mariana P.; Vieira, Gilson; Blanke, Marius; Bremmer, Frank; Sato, João R.; Kircher, Tilo; Amaro, Edson
• Is Part Of: Journal of magnetic resonance imaging. Volume 40:Issue 1(2014)
• Page Start: 37
• Page End: 46
• Publication Date: 2013-11-04
• Subjects: saccades -- eye movements -- reproducibility -- multicenter study -- fMRI; Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24369
• Languages: English
• ISSNs: 1053-1807

Abstract

Abstract : Purpose: To assess the reproducibility of brain‐activation and eye‐movement patterns in a saccade paradigm when comparing subjects, tasks, and magnetic resonance (MR) systems. Materials and Methods: Forty‐five healthy adults at two different sites ( n = 45) performed saccade tasks with varying levels of target predictability: predictable (PRED), position predictable (pPRED), time predictable (tPRED), and prosaccade (SAC). Eye‐movement pattern was tested with a repeated‐measures analysis of variance. Activation maps reproducibility were estimated with the cluster overlap Jaccard index and signal variance coefficient of determination for within‐subjects test–retest data, and for between‐subjects data from the same and different sites. Results: In all groups latencies increased with decreasing target predictability: PRED < pPRED < tPRED < SAC ( P < 0, 001). Activation overlap was good to fair (>0.40) in all tasks in the within‐subjects test–retest comparisons and poor (<0.40) in the tPRED for different subjects. The overlap of the different tasks for within‐groups data was higher (0.40–0.68) than for the between‐groups data (0.30–0.50). Activation consistency was 60–85% in the same subjects, 50–79% in different subjects, and 50–80% in different sites. In SAC, the activation found in the same and in different subjects was more consistent than in other tasks (50–80%). Conclusion: The predictive saccade tasks produced evidence for brain‐activation and eye‐movement reproducibility.J. Magn. Reson. Imaging 2014;40:37–46 . ©2013 Wiley Periodicals, Inc .