Laparotomy Cryoablation in Rabbit VX2 Pancreatic Carcinoma. Issue 3 (March 2017)

• Record Type: Journal Article
• Authors: Zhang, Wenlong; Tao, Huimin; Zeng, Jianying; Fang, Gang; Liang, Bing; Zhou, Liang; Luo, Xiaomei; Shi, Jian; Niu, Lizhi
• Is Part Of: Pancreas. Volume 46:Issue 3(2017)
• Publication Date: 2017-03
• Subjects: cryoablation -- iceball size -- laparotomy -- pancreatic carcinoma -- rabbit model -- VX2; Pancreas -- Diseases -- Periodicals; Pancreas -- Periodicals; Neuroendocrine tumors -- Periodicals; 616.37005
• DOI: 10.1097/MPA.0000000000000798
• Languages: English
• ISSNs: 0885-3177

Abstract

Abstract : Objective: The aim of this study was to establish a suitable rabbit model and select the optimal protocol for laparotomy cryoablation of pancreatic carcinoma. Methods: VX2 tumor tissues were inoculated into rabbit pancreases to build the pancreatic carcinoma model; then, the tumor-bearing rabbits were randomly divided into 4 groups: control, treatment A (the cryoablated-iceball diameter was bigger than the tumor), treatment B (iceball was as big as the tumor), and treatment C (iceball was smaller than the tumor). Related laboratory tests were conducted, and survival time was recorded. Results: The VX2 pancreatic carcinoma model was successfully established, and serum neuron-specific enolase levels increased continuously after inoculation. Compared with controls, rabbits in treatments A and C groups had no significant survival benefit ( P > 0.05), but treatment B significantly prolonged the survival time ( P < 0.01). Conclusions: VX2 pancreatic cancer model was successfully established with neuron-specific enolase as biomarker. Treatment B may be the optimal protocol for pancreatic carcinoma and a new treatment option for patients with unresectable pancreatic cancer.