Direct comparison of intra‐articular versus intravenous delayed gadolinium‐enhanced MRI of hip joint cartilage. Issue 1 (6th June 2013)

• Record Type: Journal Article
• Authors: Zilkens, Christoph; Miese, Falk; Kim, Young‐Jo; Jäger, Marcus; Mamisch, Tallal C.; Hosalkar, Harish; Antoch, Gerald; Krauspe, Rüdiger; Bittersohl, Bernd
• Is Part Of: Journal of magnetic resonance imaging. Volume 39:Issue 1(2014)
• Page Start: 94
• Page End: 102
• Publication Date: 2013-06-06
• Subjects: dGEMRIC -- cartilage -- hip joint -- 3T -- osteoarthritis; Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24096
• Languages: English
• ISSNs: 1053-1807

Abstract

Abstract : Purpose: To investigate the potential of delayed gadolinium‐enhanced magnetic resonance imaging in cartilage (dGEMRIC) after intra‐articular (ia) contrast agent administration at 3 Tesla (T), a paired study comparing intravenous (iv) dGEMRIC (standard) with ia‐dGEMRIC was performed. Materials and Methods: Thirty‐five symptomatic patients with suspected cartilage damage underwent ia ‐ and iv ‐dGEMRIC. MRI was performed with a 3T system wherein the interval between both measurements was 2 weeks. For iv ‐dGEMRIC, FDA approved Gd‐DOTA − was injected intravenously 45 min before the MRI scan. For ia ‐dGEMRIC, 10–20 mL of a 2 mM solution of Gd‐ DOTA − was injected under fluoroscopic guidance 30 min before the MRI scan. Results: Both ia ‐ and iv ‐dGEMRIC demonstrated the typical T1Gd pattern in hip joint cartilage with increasing values toward the superior regions in acetabular cartilage reflecting the higher glycosaminoglycan (GAG) content in the main weight‐bearing area. Correlation analysis revealed a moderate correlation between both techniques (r = 0.439, P ‐value < 0.001), whereas the T1Gd values for iv ‐dGEMRIC were significantly higher than those for ia ‐dGEMRIC. This corresponds with the Bland‐Altman plot analysis, which revealed a systemic bias (higher T1Gd values after iv gadolinium application) of ∼70 ms. Conclusion: Ia ‐dGEMRIC was able to reveal the characteristic T1Gd pattern in hip joint cartilage confirming the sensitivity of ia ‐dGEMRIC for GAG. In addition, there was a significant correlation between iv‐dGEMRIC and ia ‐dGEMRIC. However, the T1Gd values after ia contrast media application were significantly lower than those after iv application that has to be considered for future studies. J. Magn. Reson. Imaging 2014;39:94–102. © 2013 Wiley Periodicals, Inc.