Recent developments in radiolabelled peptides for PET imaging of cancer. Issue 37 (14th September 2016)

• Record Type: Journal Article
• Authors: Charron, Carlie L.; Farnsworth, Ashleigh L.; Roselt, Peter D.; Hicks, Rodney J.; Hutton, Craig A.
• Is Part Of: Tetrahedron letters. Volume 57:Issue 37(2016)
• Page Start: 4119
• Page End: 4127
• Publication Date: 2016-09-14
• Subjects: Molecular imaging -- Cancer -- Peptides -- Fluorine-18 -- Carbon-11 -- Radiometals; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.07.083
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Recent developments in the field of radiolabelled peptides for cancer imaging. CuAAC and cyclooctyne chemistry to attach prosthetic groups. Direct labelling using isotope exchange with Si-, B- and Al-fluorides. Novel radiometal chelators. Fluorine-18, carbon-11, gallium-68 and copper-64 isotopes. Abstract: This digest highlights recent developments in the field of molecular imaging of cancer using peptide-based targeting entities. Syntheses of novel radiolabelled prosthetic groups and new radiolabelled peptide conjugates are highlighted. This review focuses on developments made using positron emission tomography isotopes such as fluorine-18, carbon-11, gallium-68 and copper-64 within the last 5 years.