Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp. Issue 37 (14th September 2016)

• Record Type: Journal Article
• Authors: Kanamori, Yuki; Iwasaki, Arihiro; Sumimoto, Shinpei; Suenaga, Kiyotake
• Is Part Of: Tetrahedron letters. Volume 57:Issue 37(2016)
• Page Start: 4213
• Page End: 4216
• Publication Date: 2016-09-14
• Subjects: Urumamide -- Marine cyanobacteria -- Depsipeptide -- β-Amino acid -- Okeania; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.08.012
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Urumamide was discovered from a marine cyanobacterium Okeania sp. Urumamide contains several unusual peptide components such as a β-amino acid moiety. Urumamide inhibited the growth of human cancer cells and chymotrypsin. Abstract: Urumamide, a novel cyclic depsipeptide that contains a β-amino acid, was isolated from a marine cyanobacterium Okeania sp. Its gross structure was determined by spectroscopic analyses, and the absolute configuration was established based on Marfey's analyses and chiral HPLC analyses of hydrolysis products. Biologically, urumamide inhibited the growth of human cancer cells. In addition, urumamide inhibited chymotrypsin.