Genomes of early onset prostate cancer. Issue 5 (September 2017)

• Record Type: Journal Article
• Authors: Weischenfeldt, Joachim; Korbel, Jan O.
• Is Part Of: Current opinion in urology. Volume 27:Issue 5(2017:Sep.)
• Publication Date: 2017-09
• Subjects: androgen receptor -- early-onset prostate cancer -- ERG fusion gene -- genomic structural rearrangements; Urology -- Periodicals; Review Literature -- Bibliography; Review Literature -- Periodicals; Male Urogenital Diseases -- Bibliography; Male Urogenital Diseases -- Periodicals; Female Urogenital Diseases -- Bibliography; Female Urogenital Diseases -- Periodicals; Urologic Diseases -- Bibliography; Urologic Diseases -- Periodicals; Periodicals; 616.6005
• DOI: 10.1097/MOU.0000000000000422
• Languages: English
• ISSNs: 1473-6586

Abstract

Abstract : Purpose of review: Prostate cancer is a disease of the elderly but a clinically relevant subset occurs early in life. In the current review, we discuss recent findings and the current understanding of the molecular underpinnings associated with early-onset prostate cancer (PCa) and the evidence supporting age-specific differences in the cancer genomes. Recent findings: Recent surveys of PCa patient cohorts have provided novel age-dependent links between germline and somatic aberrations which points to differences in the molecular cause and treatment options. Summary: Identifying the earliest molecular alterations in PCa can provide insight into the cause of the disease and biomarkers for patient risk stratification. Genomic aberrations of early-onset PCas display several patterns distinct from late-onset PCa genomes, suggesting age-dependent pathomechanisms involving alterations in the androgen receptor pathway.