Low-Density Lipoprotein Receptor-Related Protein 4-Positive Myasthenia Gravis in a Double-Seronegative, Electromyography-Negative Patient. Issue 3 (September 2017)

• Record Type: Journal Article
• Authors: Kruger, Joshua M.; Karussis, Dimitrios; Zisimopoulou, Paraskevi; Petrou, Panayiota
• Is Part Of: Journal of neuro-ophthalmology. Volume 37:Issue 3(2017:Sep.)
• Publication Date: 2017-09
• Subjects: Neuroophthalmology -- Periodicals; 617.7
• DOI: 10.1097/WNO.0000000000000499
• Languages: English
• ISSNs: 1070-8022

Abstract

Abstract : Abstract: We describe a patient with ocular myasthenia gravis, where single-fiber electromyography and testing for acetylcholine receptor and muscle-specific kinase antibodies were negative. However, antibodies to low-density lipoprotein receptor-related protein 4 (LRP4) were positive, and this prompted appropriate management. We recommend that testing for LRP4 antibodies be considered when the clinical suspicion for myasthenia gravis is high despite negative conventional diagnostic tests.