Nivolumab-Induced Development of Pulmonary Sarcoidosis in Renal Cell Carcinoma. (September 2017)

• Record Type: Journal Article
• Authors: Zhang, Meng; Schembri, Geoffrey
• Is Part Of: Clinical nuclear medicine. Volume 42:Number 9(2017)
• Publication Date: 2017-09
• Subjects: nivolumab -- pulmonary sarcoidosis -- renal cell carcinoma; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001758
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: A 64-year-old woman with metastatic clear cell renal carcinoma who had been on nivolumab immunotherapy for 10 months was referred for a FDG PET scan to monitor disease progress. New bilateral mediastinal and hilar FDG-avid lymphadenopathy was noted. Pathology on subsequent mediastinal nodal biopsy showed well-formed epithelioid granulomas with no evidence of malignancy consistent with sarcoidosis. This case illustrates that pulmonary sarcoidosis can be induced by immunotherapy in the treatment of renal cell carcinoma.