Low 25(OH) vitamin D3 levels are associated with adverse outcome in newly diagnosed, intensively treated adult acute myeloid leukemia. Issue 4 (25th October 2013)

• Record Type: Journal Article
• Authors: Lee, Hun Ju; Muindi, Josephia R.; Tan, Wei; Hu, Qiang; Wang, Dan; Liu, Song; Wilding, Gregory E.; Ford, Laurie A.; Sait, Sheila N. J.; Block, Annemarie W.; Adjei, Araba A.; Barcos, Maurice; Griffiths, Elizabeth A.; Thompson, James E; Wang, Eunice S.; Johnson, Candace S.; Trump, Donald L.; Wetzler, Meir
• Is Part Of: Cancer. Volume 120:Issue 4(2014)
• Page Start: 521
• Page End: 529
• Publication Date: 2013-10-25
• Subjects: acute myeloid leukemia -- vitamin D -- single nucleotide polymorphism -- microRNA -- outcome; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.28368
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : BACKGROUND: Several studies have suggested that low 25(OH) vitamin D3 levels may be prognostic in some malignancies, but no studies have evaluated their impact on treatment outcome in patients with acute myeloid leukemia (AML). METHODS: Vitamin D levels were evaluated in 97 consecutive, newly diagnosed, intensively treated patients with AML. MicroRNA expression profiles and single nucleotide polymorphisms (SNPs) in the 25(OH) vitamin D3 pathway genes were evaluated and correlated with 25(OH) vitamin D3 levels and treatment outcome. RESULTS: Thirty‐four patients (35%) had normal 25(OH) vitamin D3 levels (32‐100 ng/mL), 34 patients (35%) had insufficient levels (20‐31.9 ng/mL), and 29 patients (30%) had deficient levels (<20 ng/mL). Insufficient/deficient 25(OH) vitamin D3 levels were associated with worse relapse‐free survival (RFS) compared with normal vitamin D3 levels. In multivariate analyses, deficient 25(OH) vitamin D3, smoking, European Leukemia Network genetic group, and white blood cell count retained their statistical significance for RFS. Several microRNAs and SNPs were associated with 25(OH) vitamin D3 levels, although none remained significant after multiple test corrections; one 25(OH) vitamin D3 receptor SNP, rs10783219, was associated with a lower complete remission rate ( P = .0442) and with shorter RFS ( P = .0058) and overall survival ( P = .0011). CONCLUSIONS: It remains to be determined what role microRNA and SNP profiles play in contributing to low 25(OH) vitamin D3 level and/or outcome and whether supplementation will improve outcomes for patients with AML. Cancer 2014;120:521–529 . © 2013 American Cancer Society . Abstract : Low 25(OH) vitamin D3 levels are associated with a worse outcome in patients with acute myeloid leukemia. One vitamin D3 receptor single nucleotide polymorphism, rs10783219, is associated with a worse outcome.