Improvement in survival of patients with oral cavity squamous cell carcinoma: An international collaborative study. Issue 24 (20th September 2013)

• Record Type: Journal Article
• Authors: Amit, Moran; Yen, Tzu‐Chen; Liao, Chun‐Ta; Chaturvedi, Pankaj; Agarwal, Jai Prakash; Kowalski, Luiz P.; Ebrahimi, Ardalan; Clark, Jonathan R.; Kreppel, Matthias; Zöller, Joachim; Fridman, Eran; Bolzoni, Villaret A.; Shah, Jatin P.; Binenbaum, Yoav; Patel, Snehal G.; Gil, Ziv
• Is Part Of: Cancer. Volume 119:Issue 24(2013)
• Page Start: 4242
• Page End: 4248
• Publication Date: 2013-09-20
• Subjects: oral cavity -- survival -- time -- trends -- squamous -- margins; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.28357
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : BACKGROUND: An association between the survival of patients with oral cavity squamous cell carcinoma (OCSCC) and advancements in diagnosis and therapy has not been established. METHODS: This was a retrospective, longitudinal, international, population‐based study of 2738 patients who underwent resection of OCSCC during 2 different decades. Characteristics of patients from 7 international cancer centers who received treatment between 1990 and 2000 (group A; n = 735) were compared with patients who received treatment between 2001 and 2011 (group B; n = 2003). RESULTS: Patients in group B had more advanced tumors and tended to develop distant metastases more frequently than patients in group A ( P = .005). More group B patients underwent selective neck dissection and received adjuvant radiotherapy ( P < .001). Outcome analysis revealed a significant improvement in 5‐year overall survival, from 59% for group A to 70% for group B ( P < .001). There was also a significant improvement in disease‐specific survival associated with operations performed before and after 2000 (from 69% to 81%, respectively; P < .001). Surgery after 2000, negative margins, adjuvant treatment, and early stage disease were independent predictors of a better outcome in multivariate analysis. The decade of treatment was an independent prognostic factor for cancer‐specific mortality (hazard ratio, 0.42; 95% confidence interval, 0.3‐0.6). CONCLUSIONS: The survival rate of patients with OCSCC improved significantly during the past 2 decades despite older age, more advanced disease stage, and a higher rate of distant metastases. The current results suggest that the prognosis for patients with OCSCC has improved over time, presumably because of advances in imaging and therapy. Cancer 2013;119:4242–4248 . © 2013 American Cancer Society . Abstract : The survival rate of patients with oral cavity cancer has improved significantly during the past 2 decades despite higher stage disease, and a higher rate of distant metastases. The decade of treatment is identified as an independent prognostic factor for outcome with a hazard ratio of 0.42 for cancer‐specific mortality.