Inside Cover: Design, Synthesis, and Antibacterial Activity of Demethylvancomycin Analogues against Drug‐Resistant Bacteria (ChemMedChem 6/2013). Issue 6 (24th May 2013)

• Record Type: Journal Article
• Authors: Chang, Jun; Zhang, Si‐Ji; Jiang, Yong‐Wei; Xu, Liang; Yu, Jian‐Ming; Zhou, Wen‐Jiang; Sun, Xun
• Is Part Of: ChemMedChem. Volume 8:Issue 6(2013:Jun.)
• Page Start: 866
• Page End: 866
• Publication Date: 2013-05-24
• Subjects: antibiotics -- demethylvancomycin -- drug resistance -- structure–activity relationships -- synthesis design; Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201390021
• Languages: English
• ISSNs: 1860-7179

Abstract

Abstract : The inside cover picture shows the proposed binding mode of a demethylvancomycin analogue (white) with the peptidoglycan of vancomycin‐resistant Enterococcus faecalis (teal), in which the NH–π interaction is predicted to compensate for the diminished binding affinity caused by the breaking of a conserved NH ⋅ ⋅ ⋅ O hydrogen bond in drug‐resistant bacteria. For more details, see the Full Paper by Wen‐Jiang Zhou, Xun Sun et al. onp. 976 ff.