Azahelicene Superbases as MAILD Matrices for Acidic Analytes1. Issue 9 (19th August 2013)

• Record Type: Journal Article
• Authors: Napagoda, Mayuri; Rulíšek, Lubomír; Jančařík, Andrej; Klívar, Jiří; Šámal, Michal; Stará, Irena G.; Starý, Ivo; Šolínová, Veronika; Kašička, Václav; Svatoš, Aleš
• Is Part Of: ChemPlusChem. Volume 78:Issue 9(2013:Sep.)
• Page Start: 937
• Page End: 942
• Publication Date: 2013-08-19
• Subjects: helicenes -- laser spectroscopy -- mass spectrometry -- matrix isolation -- metabolomics; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cplu.201300258
• Languages: English
• ISSNs: 2192-6506

Abstract

Abstract : Fitting the profile : A superbasic 1, 14‐diaza[5]helicene can serve as an efficient, ionless matrix for matrix‐assisted ionization/laser desorption (MAILD) spectrometry. The matrix outperforms other bases by acting as a kinetically active proton sponge and is highly suitable for high‐throughput metabolomics analysis. There is a correlation between the basicity (and proton‐sponge character) of matrices and their efficacy in MAILD‐MS.