Progressive multifocal leukoencephalopathy in two natalizumab-treated stepsisters: An intriguing coincidence. (February 2017)

• Record Type: Journal Article
• Authors: Bacchetta, Frédéric; Mathias, Amandine; Schluep, Myriam; Du Pasquier, Renaud
• Is Part Of: Multiple sclerosis. Volume 23:Number 2(2017)
• Page Start: 300
• Page End: 303
• Publication Date: 2017-02
• Subjects: Natalizumab -- JC virus -- progressive multifocal leukoencephalopathy -- multiple sclerosis -- transmission; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458516670734
• Languages: English
• ISSNs: 1352-4585

Abstract

Background: Natalizumab, a treatment used in multiple sclerosis (MS), is associated with cases of progressive multifocal leukoencephalopathy (PML). Objective: We describe two cases of PML in related but not genetically apparented natalizumab-treated MS patients who are stepsisters. Reported cases/outcomes: While Patient 1 developed PML, Patient 2 was on natalizumab and had contacts with Patient 1. Patient 2 was diagnosed with PML 5 months after Patient 1. Conclusion: The clinical and temporal data highly suggest that there was JC virus (JCV) transmission from one patient to the other with development of PML as primo-infection in Patient 2.