Genetic and intermediate phenotypic susceptibility markers of gastric cancer in Hispanic Americans: A case‐control study. Issue 19 (24th June 2014)

• Record Type: Journal Article
• Authors: Sun, Yuhui; Gu, Jian; Ajani, Jaffer A.; Chang, David W.; Wu, Xifeng; Stroehlein, John R.
• Is Part Of: Cancer. Volume 120:Issue 19(2014)
• Page Start: 3040
• Page End: 3048
• Publication Date: 2014-06-24
• Subjects: single nucleotide polymorphism -- gastric cancer -- mitochondrial DNA -- copy number -- telomere length -- Hispanics; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.28792
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : BACKGROUND: Hispanics are the largest nonwhite ethnic group in the US population, and they have higher incidence and mortality rates for gastric cancer (GC) than whites and Asians. Studies have identified several genetic susceptibility loci and intermediate phenotypic biomarkers for GC in whites and Asians. No studies have evaluated genetic susceptibility and intermediate phenotypic biomarkers in Hispanics. METHODS: In a case‐control study of 132 Hispanic patients with GC (cases) and a control group of 125 Hispanics (controls), the authors evaluated the association of 5 single nucleotide polymorphisms (SNPs) that predispose whites and/or Asians to GC and of 2 intermediate phenotypic markers in peripheral blood leukocytes, ie, telomere length and mitochondrial DNA (mtDNA) copy number, with the GC risk. RESULTS: The variant C allele of the reference SNP rs2294008 in the PSCA gene was associated with a significantly reduced risk of GC (per allele‐adjusted odds ratio [aOR], 0.51; 95% confidence interval [CI], 0.33‐0.77; P = .002). Leukocyte mtDNA copy numbers were significantly lower in GC cases (mean ± standard deviation, 0.91 ± 0.28) than in controls (1.29 ± 0.42; P < .001). When individuals were dichotomized into high and low mtDNA copy number groups based on the median mtDNA copy number value in the controls, those who had a low mtDNA copy number had a significantly increased risk of GC (aOR, 11.00; 95% CI, 4.79‐25.23; P < .001) compared with those who had a high mtDNA copy number. Telomere length was not associated significantly with the risk of GC (aOR, 1.21; 95% CI, 0.65‐2.27; P = .551). CONCLUSIONS: Hispanics share certain genetic susceptibility loci and intermediate phenotypic GC biomarkers with whites and Asians and may also have distinct genetic susceptibility factors. Cancer 2014;120:3040–3048 . © 2014 American Cancer Society . Abstract : This is the first epidemiological study to examine the association of single nucleotide polymorphisms, leukocyte mitochondrial DNA copy number, and leukocyte telomere length with the risk of gastric cancer (GC) among Hispanics. The results indicate that reference single nucleotide polymorphism rs2294008 in the PSCA gene and leukocyte mitochondrial DNA copy numbers are associated significantly with the risk of GC, but leukocyte telomere length is not, suggesting that GC among Hispanics has both common and distinct biology compared with GC among other ethnic groups.