Tumor-induced Osteomalacia in a 3-Year-Old With Unresectable Central Giant Cell Lesions. Issue 1 (January 2017)

• Record Type: Journal Article
• Authors: Crossen, Stephanie S.; Zambrano, Eduardo; Newman, Beverley; Bernstein, Jonathan A.; Messner, Anna H.; Bachrach, Laura K.; Twist, Clare J.
• Is Part Of: Journal of pediatric hematology/oncology. Volume 39:Issue 1(2017)
• Publication Date: 2017-01
• Subjects: tumor-induced osteomalacia -- central giant cell lesion -- fibroblast growth factor 23; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000000686
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Tumor-induced osteomalacia (TIO) is a rare cause of hypophosphatemia involving overproduction of fibroblast growth factor 23. TIO has been described largely in adults with small mesenchymal tumors. We report a case of TIO in a child who presented with knee pain and radiographic findings concerning for rickets, and was found to have maxillomandibular giant cell lesions. The patient was treated with oral phosphorus and calcitriol, surgical debulking, and intralesional corticosteroids, which resulted in tumor regression and normalization of serum fibroblast growth factor 23 and phosphorus. This case illustrates the occurrence of this rare paraneoplastic syndrome in children and adds to our knowledge about clinical manifestations and pathologic findings associated with pediatric TIO.