Bimetallic Pt–Sn/γ-Al2O3 catalyzed β-alkylation of secondary alcohols with primary alcohols under solvent-free conditions. Issue 36 (7th September 2016)

• Record Type: Journal Article
• Authors: Wu, Kaikai; He, Wei; Sun, Chenglin; Yu, Zhengkun
• Is Part Of: Tetrahedron letters. Volume 57:Issue 36(2016)
• Page Start: 4017
• Page End: 4020
• Publication Date: 2016-09-07
• Subjects: Alcohols -- β-Alkylation -- C–C bond formation -- Hydrogen borrowing -- Pt–Sn catalyst; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.07.037
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Pt–Sn/γ-Al2 O3 catalyzed β-alkylation of secondary alcohols with primary alcohols. The reaction underwent through a hydrogen borrowing strategy. Atom-economical and environmentally benign C–C bond formation is presented. Abstract: Heterogeneous bimetallic Pt–Sn/γ-Al2 O3 (0.5 wt% Pt, molar ratio Pt:Sn = 1:3) was successfully utilized as the catalyst for direct β-alkylation of secondary alcohols with primary alcohols under solvent-free conditions. β-Alkylated secondary alcohols were obtained in moderate to high yields with water formed as the by-product through a hydrogen borrowing pathway. The present protocol provides a concise atom-economical and environmentally benign method for C–C bond formation.