Iron-catalyzed arylmethylation of sulfonyl acrylamides. Issue 36 (7th September 2016)

• Record Type: Journal Article
• Authors: Yu, Jin-Tao; Hu, Weiming; Peng, Haibo; Cheng, Jiang
• Is Part Of: Tetrahedron letters. Volume 57:Issue 36(2016)
• Page Start: 4109
• Page End: 4112
• Publication Date: 2016-09-07
• Subjects: Arylmethylation -- Radical aryl migration -- Iron -- Desulfonylation -- Sulfonyl acrylamides; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.07.105
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: An iron-catalyzed arylmethylation of activated alkenes was developed. Di- tert -butyl peroxide (DTBP) served as the methyl radical source. The cascade methyl radical addition, 1, 4-aryl migration, and desulfonylation was involved. Abstract: A novel iron-catalyzed arylmethylation of activated alkenes was developed using di- tert -butyl peroxide (DTBP) as the methyl radical source. This cascade process involved the sequential methyl radical addition, 1, 4-aryl migration, and desulfonylation of sulfonyl acrylamides to afford a variety of α-aryl-β-methyl amides in good to moderate yields.