The Vietnamese Pig as a Translational Animal Model to Evaluate Tissue Engineered Heart Valves: Promising Early Experience. Issue 4 (April 2017)

• Record Type: Journal Article
• Authors: Gallo, Michele; Poser, Helen; Bottio, Tommaso; Bonetti, Antonella; Franci, Paolo; Naso, Filippo; Buratto, Edward; Zanella, Fabio; Perona, Giovanni; Dal Lin, Carlo; Bianco, Roberto; Spina, Michele; Busetto, Roberto; Marchini, Maurizio; Ortolani, Fulvia; lop, Laura; Gerosa, Gino
• Is Part Of: International journal of artificial organs. Volume 40:Issue 4(2017:Apr.)
• Page Start: 142
• Page End: 149
• Publication Date: 2017-04
• Subjects: Animal model -- Decellularization -- Preclinical study -- Tissue engineered heart valve -- Vietnamese pig; Artificial organs -- Periodicals; 617.956
• DOI: 10.5301/ojao.5000568
• Languages: English
• ISSNs: 0391-3988

Abstract

Several animal models are currently used for the surgical implantation of either biologic or biopolymeric scaffolds in order to provide in vivo assessment of tissue-engineered heart valves. The Vietnamese pig (VP) is herein proposed as a suitable recipient to test the function of novel bioengineered valve substitutes, in the reconstruction of the right ventricular outflow tract (RVOT). This review aims to provide a complete and exhaustive panel of physiological parameters and methodological information for preclinical studies of tissue-engineered heart valves in the VP animal model.