Biothiol-triggered, self-disassembled silica nanobeads for intracellular drug delivery. (1st September 2015)

• Record Type: Journal Article
• Authors: Huang, Xin-Chun; Wu, Li-Bang; Hsu, Jen-Fang; Shigeto, Shinsuke; Hsu, Hsin-Yun
• Is Part Of: Acta biomaterialia. Volume 23(2015)
• Page Start: 263
• Page End: 270
• Publication Date: 2015-09-01
• Subjects: Drug delivery -- Silica nanoparticles -- Sol–gel processes -- Self-disassembly -- Biothiols; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1016/j.actbio.2015.05.006
• Languages: English
• ISSNs: 1742-7061

Abstract

Graphical abstract: Abstract: Silica-based nanomaterials have demonstrated great potential in biomedical applications due to their chemical inertness. However, the degradability and endosomal trapping issues remain as rate-limiting barriers during their innovation. In this study, we provide a simple yet novel sol–gel approach to construct the redox-responsive silica nanobeads (ReSiNs), which could be rapidly disassembled upon redox gradient for intracellular drug delivery. The disulfide-linked scaffold of the nanobead was synthesized by employing the dithiobis-(succinimidyl propionate) to bridge (3-aminopropyl)-trimethoxysilane. Such silica matrix could be efficiently disrupted in response to intracellular glutathione, resulting in drug release and collapse of entire nanocarrier. Moreover, the ReSiNs exhibited insignificant cytotoxicity before and after the degradation. These results indicated the potential of using ReSiNs as a novel silica-based, biothiol-degradable nanoplatform for future drug delivery.