Lack of control of hypertension in primary cardiovascular disease prevention in Europe: Results from the EURIKA study. (1st September 2016)

• Record Type: Journal Article
• Authors: Borghi, Claudio; Tubach, Florence; De Backer, Guy; Dallongeville, Jean; Guallar, Eliseo; Medina, Jesús; Perk, Joep; Roy, Carine; Banegas, José R.; Rodriguez-Artalejo, Fernando; Halcox, Julian P.
• Is Part Of: International journal of cardiology. Volume 218(2016)
• Page Start: 83
• Page End: 88
• Publication Date: 2016-09-01
• Subjects: ACE angiotensin-converting enzyme -- BMI body mass index -- CI confidence interval -- CVD cardiovascular disease -- DBP diastolic blood pressure -- ESC European Society of Cardiology -- ESH European Society of Hypertension -- EURIKA European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice -- HbA1c glycated haemoglobin -- HDL-C high-density lipoprotein cholesterol -- LDL-C low-density lipoprotein cholesterol -- OR odds ratio -- SCORE Systematic Coronary Risk Evaluation -- SBP systolic blood pressure -- SD standard deviation; Hypertension -- Cardiovascular disease -- Observational study -- Primary prevention -- Risk factor; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2016.05.044
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: The prevalence of and factors associated with uncontrolled hypertension and apparent resistant hypertension were assessed in the European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (EURIKA;NCT00882336 ). Methods: EURIKA was a cross-sectional observational study including patients being treated for the primary prevention of cardiovascular disease in 12 European countries. Patients were assessed if they were being treated for hypertension (N = 5220). Blood pressure control was defined according to European guidelines, with sensitivity analysis taking account of patients' age and diabetes status. Associated factors were assessed using multivariate analysis. Results: In the primary analysis, a total of 2691 patients (51.6%) had uncontrolled hypertension. Factors significantly associated with an increased risk of having uncontrolled hypertension included female sex (odds ratio [OR]: 2.29; 95% confidence interval [CI]: 1.93–2.73), body mass index (BMI; OR per kg/m 2 : 1.03; 95% CI: 1.01–1.04), and geographic location. A total of 749 patients (14.3%) had apparent resistant hypertension. Factors significantly associated with an increased risk of having apparent resistant hypertension included BMI (OR per kg/m 2 : 1.06; 95% CI: 1.04–1.08), diabetes (OR: 1.28; 95% CI: 1.06–1.53), use of statins (OR: 1.36; 95% CI: 1.15–1.62), serum uric acid levels (OR: 1.16; 95% CI: 1.09–1.23), and geographic location. Similar results were seen in sensitivity analyses. Conclusions: Over 50% of patients treated for hypertension continued to have uncontrolled blood pressure and 14.3% had apparent resistant hypertension. Positive associations were seen with other cardiovascular risk factors. Highlights: EURIKA was a cross-sectional observational study in 12 European countries. Uncontrolled hypertension was assessed among patients treated for hypertension. More than half of all treated patients continued to have uncontrolled hypertension. Approximately 14% had apparent resistant hypertension. Associations were seen between hypertension and other cardiovascular risk factors.