Proteoglycans and Glycosaminoglycans Improve Toughness of Biocompatible Double Network Hydrogels. (22nd October 2013)

• Record Type: Journal Article
• Authors: Zhao, Yu; Nakajima, Tasuku; Yang, Jing Jing; Kurokawa, Takayuki; Liu, Jian; Lu, Jishun; Mizumoto, Shuji; Sugahara, Kazuyuki; Kitamura, Nobuto; Yasuda, Kazunori; Daniels, A. U. D.; Gong, Jian Ping
• Is Part Of: Advanced materials. Volume 26:Number 3(2014)
• Page Start: 436
• Page End: 442
• Publication Date: 2013-10-22
• Subjects: hydrogels -- proteoglycans -- glycosaminoglycans -- toughness -- biocompatibility; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201303387
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : Based on the molecular stent concept, a series of tough double‐network hydrogels (St‐DN gels) made from the components of proteoglycan aggregates – chondroitin sulfate proteoglycans (1), chondroitin sulfate (2), and sodium hyaluronate (3) – are successfully developed in combination with a neutral biocompatible polymer. This work demonstrates a promising method to create biopolymer‐based tough hydrogels for biomedical applications.