Palladium‐Catalyzed Decarboxylative Coupling of α‐ Oxocarboxylic Acids with C(sp2)H of 2‐Aryloxypyridines. Issue 8 (17th May 2013)

• Record Type: Journal Article
• Authors: Yao, Jinzhong; Feng, Ruokun; Wu, Zaihong; Liu, Zhanxiang; Zhang, Yuhong
• Is Part Of: Advanced synthesis & catalysis. Volume 355:Issue 8(2013)
• Page Start: 1517
• Page End: 1522
• Publication Date: 2013-05-17
• Subjects: 2‐aryloxypyridines -- CH acylation -- decarboxylative coupling -- α‐oxocarboxylic acids -- palladium; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201300078
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: An efficient palladium‐catalyzed decarboxylative ortho ‐acylation of 2‐aryloxypyridines with α‐oxocarboxylic acids is described. In this new transformation, the aromatic C( sp 2 )H bond was successfully acylated to give diverse aromatic ketones regioselectively in moderate to good yields. The pyridine group can be removed easily after the acylation to give the corresponding 2‐hydroxy aromatic ketones. Abstract :