Enantioselective Synthesis of Putative Lipiarmycin Aglycon Related to Fidaxomicin/Tiacumicin B1. (24th November 2014)
- Record Type:
- Journal Article
- Title:
- Enantioselective Synthesis of Putative Lipiarmycin Aglycon Related to Fidaxomicin/Tiacumicin B1. (24th November 2014)
- Main Title:
- Enantioselective Synthesis of Putative Lipiarmycin Aglycon Related to Fidaxomicin/Tiacumicin B1
- Authors:
- Erb, William
Grassot, Jean‐Marie
Linder, David
Neuville, Luc
Zhu, Jieping - Abstract:
- Abstract: An enantioselective synthesis of a putative lipiarmycin aglycon was accomplished and features: 1) Brown′s enantioselective alkoxyallylboration and allylation of aldehydes, 2) chain elongation by iterative Horner–Wadsworth–Emmons olefination, 3) Evans' aldol reaction and 4) an ene‐diene ring‐closing metathesis. A neighboring‐group‐assisted chemoselective reductive desilylation was uncovered in this study and was instrumental to the realization of the present synthesis.
- Is Part Of:
- Angewandte Chemie. Volume 127:Number 6(2015)
- Journal:
- Angewandte Chemie
- Issue:
- Volume 127:Number 6(2015)
- Issue Display:
- Volume 127, Issue 6 (2015)
- Year:
- 2015
- Volume:
- 127
- Issue:
- 6
- Issue Sort Value:
- 2015-0127-0006-0000
- Page Start:
- 1949
- Page End:
- 1952
- Publication Date:
- 2014-11-24
- Subjects:
- Makrocyclen -- Metathese -- Naturstoffe -- Schutzgruppen -- Totalsynthese
Chemistry -- Periodicals
540 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/ange.201409475 ↗
- Languages:
- English
- ISSNs:
- 0044-8249
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0902.000000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 8057.xml