Dual epigenetic modifiers for cancer therapy. (4th July 2017)
- Record Type:
- Journal Article
- Title:
- Dual epigenetic modifiers for cancer therapy. (4th July 2017)
- Main Title:
- Dual epigenetic modifiers for cancer therapy
- Authors:
- José-Enériz, Edurne San
Rabal, Obdulia
Agirre, Xabier
Oyarzabal, Julen
Prosper, Felipe - Abstract:
- ABSTRACT: Epigenetic drug discovery is an emerging strategy for the treatment of cancer and other pathologies. Here, we discuss our recent discovery of first-in-class dual reversible inhibitors of the histone methyltransferase activity of G9a/EHMT2 and DNA methyltransferases showing in vivo efficacy in human tumors. Current and future investigation lines are presented.
- Is Part Of:
- Molecular & cellular oncology. Volume 4:Number 4(2017)
- Journal:
- Molecular & cellular oncology
- Issue:
- Volume 4:Number 4(2017)
- Issue Display:
- Volume 4, Issue 4 (2017)
- Year:
- 2017
- Volume:
- 4
- Issue:
- 4
- Issue Sort Value:
- 2017-0004-0004-0000
- Page Start:
- Page End:
- Publication Date:
- 2017-07-04
- Subjects:
- Cancer -- DNMT -- drug discovery -- epigenetic -- G9a
Tumors -- Periodicals
Neoplasms
Periodicals
616.99 - Journal URLs:
- http://www.tandfonline.com/loi/kmco20#.VyIIeFL2aic ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/23723556.2017.1342748 ↗
- Languages:
- English
- ISSNs:
- 2372-3556
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 8035.xml