Fine particulate matter exposure and incidence of stroke: A cohort study in Hong Kong. (2nd May 2017)

• Record Type: Journal Article
• Authors: Qiu, Hong; Sun, Shengzhi; Tsang, Hilda; Wong, Chit-Ming; Lee, Ruby Siu-yin; Schooling, C. Mary; Tian, Linwei
• Is Part Of: Neurology. Volume 88:Number 18(2017)
• Publication Date: 2017-05-02
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Neurologie -- Périodiques; 616.8
• DOI: 10.1212/WNL.0000000000003903
• Languages: English
• ISSNs: 0028-3878

Abstract

Abstract : Objective: We aimed to assess the association of long-term residential exposure to fine particulate matter (PM) with aerodynamic diameter less than 2.5 μm (PM2.5 ) with the incidence of stroke and its major subtypes. Methods: We ascertained the first occurrence of emergency hospital admission for stroke in a Hong Kong Chinese cohort of 66, 820 older people (65+ years) who enrolled during 1998–2001 (baseline) and were followed up to December 31, 2010. High-resolution (1 × 1 km) yearly mean concentrations of PM2.5 were predicted from local monitoring data and US National Aeronautics and Space Administration satellite data using linear regression. Baseline residential PM2.5 exposure was used as a proxy for long-term exposure. We used Cox proportional hazards to evaluate the risk of incident stroke associated with PM2.5 exposure adjusted for potential confounders, including individual and neighborhood factors. Results: Over a mean follow-up of 9.4 years, we ascertained 6, 733 cases of incident stroke, of which 3, 526 (52.4%) were ischemic and 1, 175 (17.5%) were hemorrhagic. The hazard ratio for every 10 μg/m 3 higher PM2.5 concentration was statistically significant at 1.21 (95% confidence interval [CI] 1.04–1.41) for ischemic and non-statistically significant at 0.90 (95% CI 0.70–1.17) for hemorrhagic stroke in fully adjusted model 3. The estimates for ischemic stroke were higher in older participants (>70 years), less educated participants, and in men for current smokers. Conclusion: Long-term PM2.5 exposure was associated with higher risk of incident ischemic stroke, but the association with incident hemorrhagic stroke was less clear.