18F-FDG Superscan Caused by Extensive Bone Marrow Involvement in Hemophagocytic Lymphohistiocytosis. (August 2017)

• Record Type: Journal Article
• Authors: Law, W. Phillip; Emmett, Shannon; Jackson, Peter
• Is Part Of: Clinical nuclear medicine. Volume 42:Number 8(2017)
• Publication Date: 2017-08
• Subjects: FDG -- hemophagocytic -- lymphohistiocytosis -- PET; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001699
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: An 82-year-old woman who initially presented with pulmonary infection had persistent pancytopenia, which presented a diagnostic dilemma requiring multiple bone marrow biopsies for eventual diagnosis of hemophagocytic lymphohistiocytosis. This case highlights the utility of FDG PET in ( a ) focusing attention on the bone marrow and reticuloendothelial system as the primary site of pathology and ( b ) excluding underlying malignancy and infection in this rare but potentially fatal hyperinflammatory condition caused by a highly stimulated but ineffective immune response.