CLINICOPATHOLOGIC CORRELATION OF RETINAL ANGIOMATOUS PROLIFERATION TREATED WITH RANIBIZUMAB. Issue 8 (August 2017)

• Record Type: Journal Article
• Authors: Skalet, Alison H.; Miller, Audra K.; Klein, Michael L.; Lauer, Andreas K.; Wilson, David J.
• Is Part Of: Retina. Volume 37:Issue 8(2017:Aug.)
• Publication Date: 2017-08
• Subjects: age-related macular degeneration -- anti-VEGF -- choroidal neovascularization -- retinal neovascularization -- clinicopathologic correlation -- ranibizumab -- retinal angiomatous proliferation; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000001672
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To describe histopathologic features of an eye with retinal angiomatous proliferation (RAP) secondary to age-related macular degeneration treated with serial ranibizumab injections and to correlate these findings with spectral domain optical coherence tomography. Methods: Histopathologic features from serial sections through the globe of a 93-year-old man with age-related macular degeneration were studied and compared with spectral domain optical coherence tomography images obtained 7 weeks before his death. Results: The pathologic correlate of ranibizumab-treated RAP was a circumscribed, branching paucicellular vascular complex extending from the inner plexiform layer to Bruch membrane. The histopathologic findings corresponded to an area of hyperreflectivity on spectral domain optical coherence tomography imaging, substantiating the reported tomographic appearance of RAP lesions. A frank anastomosis with choroidal or retinal vasculature was not seen in this treated RAP lesion. There was a lack of retinal pigment epithelium underlying the lesion in an area of retinal pigment epithelium detachment. The elastic portion of Bruch membrane appeared intact. Treatment with ranibizumab over an extended period of time may have been associated with a loss of cellularity of the RAP lesion. Conclusion: In a patient with ARMD extensively treated with ranibizumab, color fundus photography, fluorescein angiography and SD-OCT images of RAP correlated histopathologically with a paucicellular intraretinal vascular complex. Abstract : The histopathologic features of an eye with retinal angiomatous proliferation treated with serial ranibizumab injections were correlated with the findings on spectral domain optical coherence tomography. The histopathologic findings corresponded to an area of hyperreflectivity on spectral domain optical coherence tomography imaging, substantiating the reported tomographic appearance of retinal angiomatous proliferation lesions.