Detrimental effects of a bout of physical exercise on circulating endogenous inhibitors of endothelial function in patients with coronary artery disease. Issue 8 (August 2017)

• Record Type: Journal Article
• Authors: Ilic, Marina Deljanin; Pavlovic, Radmila; Lazarevic, Gordana; Zivanovic, Slavoljub; Cvetkovic, Tatjana; Kocic, Gordana; Ilic, Stevan; Ambrosio, Giuseppe
• Is Part Of: Journal of cardiovascular medicine. Volume 18:Issue 8(2017:Aug.)
• Publication Date: 2017-08
• Subjects: asymmetric dimethylarginine -- coronary artery disease -- endothelial function -- nitric oxide -- physical exercise -- symmetric dimethylarginine; Cardiology -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; Cardiology -- Periodicals; Cardiovascular Diseases -- Periodicals; 616.1005
• DOI: 10.2459/JCM.0000000000000400
• Languages: English
• ISSNs: 1558-2027

Abstract

Abstract : Background: A bout of intense physical activity has been shown to transiently impair endothelial function; however, the underlying mechanisms are unclear. Aim: The purpose of the review was to assess the impact of a bout of physical exercise induced by exercise stress echocardiography, on blood concentration of the endogenous inhibitors of nitric oxide synthase, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA), in patients with atherosclerosis. Methods: Overall, 83 study participants were enrolled, 25 coronary artery disease (CAD) patients, 20 age and sex-matched asymptomatic study participants with at least one risk factor for CAD, and 38 healthy controls. Results: Patients with CAD developed symptoms and/or left ventricular wall motion abnormalities during exercise; no changes were seen in study participants with risk factors, or in healthy controls. At baseline, in CAD patients and in study participants with risk factors, both ADMA and SDMA were higher than healthy controls ( P < 0.001). However, a further large increase occurred during exercise stress echocardiography in both groups, regardless of development of symptoms ( P < 0.001). Conclusion: Basal concentrations of ADMA and SDMA are high in CAD patients and in study participants with risk factors, consistent with impaired nitric oxide synthase activity in atherosclerosis. Large increase of these endogenous inhibitors of nitric oxide during intense exercise provide support to the hypothesis that in patients with atherosclerosis endothelial function may further deteriorate as a consequence of a bout of physical activity.