Use of Statins and Outcomes in Intracerebral Hemorrhage Patients. Issue 8 (August 2017)

• Record Type: Journal Article
• Authors: Siddiqui, Fazeel M.; Langefeld, Carl D.; Moomaw, Charles J.; Comeau, Mary E.; Sekar, Padmini; Rosand, Jonathan; Kidwell, Chelsea S.; Martini, Sharyl; Osborne, Jennifer L.; Stutzman, Sonja; Hall, Christiana; Woo, Daniel
• Is Part Of: Stroke. Volume 48:Issue 8(2017)
• Publication Date: 2017-08
• Subjects: intracerebral hemorrhage -- hematoma -- hydroxymethylglutaryl-CoA reductase inhibitors -- mortality -- outcome; Cerebrovascular disease -- Periodicals; Cerebral circulation -- Periodicals; 616.81
• DOI: 10.1161/STROKEAHA.117.017358
• Languages: English
• ISSNs: 0039-2499

Abstract

Abstract : Background and Purpose—: Statin use may be associated with improved outcome in intracerebral hemorrhage patients. However, the topic remains controversial. Our analysis examined the effect of prior, continued, or new statin use on intracerebral hemorrhage outcomes using the ERICH (Ethnic/Racial Variations of Intracerebral Hemorrhage) data set. Methods—: We analyzed ERICH (a multicenter study designed to examine ethnic variations in the risk, presentation, and outcomes of intracerebral hemorrhage) to explore the association of statin use and hematoma growth, mortality, and 3-month disability. We computed subset analyses with respect to 3 statin categories (prior, continued, or new use). Results—: Two thousand four hundred and fifty-seven enrolled cases (mean age, 62 years; 42% females) had complete data on mortality and 3-month disability (modified Rankin Scale). Among those, 1093 cases were on statins (prior, n=268; continued, n=423; new, n=402). Overall, statin use was associated with reduced mortality and disability without any effect on hematoma growth. This association was primarily driven by continued/new statin use. A multivariate analysis adjusted for age and major predictors for poor outcome showed that continued/new statins users had good outcomes compared with prior users. However, statins may have been continued/started more frequently among less severe patients. When a propensity score was developed based on factors that could influence a physician's decision in prescribing statins and used as a covariate, continued/new statin use was no longer a significant predictor of good outcome. Conclusions—: Although statin use, especially continued/new use, was associated with improved intracerebral hemorrhage outcomes, this effect may merely reflect the physician's view of a patient's prognosis rather than a predictor of survival. Abstract : Supplemental Digital Content is available in the text.