Numerical modeling of compensation mechanisms for peripheral arterial stenoses. (1st March 2016)

• Record Type: Journal Article
• Authors: Drzisga, D.; Köppl, T.; Pohl, U.; Helmig, R.; Wohlmuth, B.
• Is Part Of: Computers in biology and medicine. Volume 70(2016)
• Page Start: 190
• Page End: 201
• Publication Date: 2016-03-01
• Subjects: Reduced model -- Peripheral stenosis -- Arteriogenesis -- Metabolic regulation -- Numerical method of characteristics; Medicine -- Data processing -- Periodicals; Biology -- Data processing -- Periodicals; 610.285
• DOI: 10.1016/j.compbiomed.2016.01.015
• Languages: English
• ISSNs: 0010-4825

Abstract

Abstract: The goal of this paper is to develop a numerical model for physiological mechanisms that help to compensate reduced blood flow caused by a peripheral arterial stenosis. Thereby we restrict ourselves to the following compensation mechanisms: Metabolic regulation and arteriogenesis, i.e., growth of pre-existing collateral arteries. Our model is based on dimensionally reduced differential equations to simulate large time periods with low computational cost. As a test scenario, we consider a stenosis located in the right posterior tibial artery of a human. We study its impact on blood supply for different narrowing degrees by the help of numerical simulations. Moreover, the efficiency of the above compensation mechanisms is examined. Our results reveal that even a complete occlusion of this artery exhibiting a cross-section area of 0.442 cm 2 can be compensated at rest, if metabolic regulation is combined with collateral arteries whose total cross-section area accounts for 8.14% of the occluded artery. Abstract : Highlights: Dimensionally reduced models for arterial blood flow are presented. The impact of peripheral arterial stenoses on blood flow is studied. It is investigated to what extent metabolic regulation and arteriogenesis are able to recover reduced blood flow caused by a peripheral stenosis.