Acute Hepatocellular Jaundice After Dofetilide Initiation: A Case Report. (February 2018)

• Record Type: Journal Article
• Authors: Rose, Patrick Gary; Seabury, Robert; Cwikla, Gregory
• Is Part Of: Hospital pharmacy. Volume 53:Number 1(2018)
• Page Start: 55
• Page End: 58
• Publication Date: 2018-02
• Subjects: adverse drug reactions -- adverse drug reactions reporting/monitoring -- cardiac agents -- cardiovascular -- gastrointestinal disorders; Hospital pharmacies -- Periodicals; Pharmacy Service, Hospital; Hospital pharmacies; Periodicals; Periodicals; 615.1
• DOI: 10.1177/0018578717738079
• Languages: English
• ISSNs: 0018-5787

Abstract

Dofetilide's hepatotoxicity is not well described. In this case report, we describe acute hepatocellular jaundice related to dofetilide use in a 33-year-old male being treated for atrial fibrillation. Both viral and ischemic causes of hepatocellular damage were ruled out as unlikely in this case. This case report outlines a rare yet probable report of idiosyncratic dofetilide-induced liver injury.