Fresh layers of RNA-mediated regulation in Gram-positive bacteria. (April 2016)

• Record Type: Journal Article
• Authors: Bouloc, Philippe; Repoila, Francis
• Is Part Of: Current opinion in microbiology. Volume 30(2016)
• Page Start: 30
• Page End: 35
• Publication Date: 2016-04
• Subjects: Microbiology -- Periodicals; 579.05
• DOI: 10.1016/j.mib.2015.12.008
• Languages: English
• ISSNs: 1369-5274

Abstract

Highlights: 5′UTRs should be considered as putative trans -acting RNA regulators. Long 3′UTRs in Gram-positive species could be putative regulatory elements. Riboswitch-controlled regulatory RNAs form a new layer of complexity. Not all lessons from E. coli apply to Gram-positive bacteria: the Hfq case. Abstract : Bacterial regulatory RNAs have been defined as diverse classes of cis and trans elements that may intervene at each step of gene expression, from RNA and protein synthesis to degradation. Here, we report on a few examples from Gram-positive bacteria that extend the definition of regulatory RNAs to include 5′ and 3′ UTRs that also act as cis and trans regulators. New examples unveil the existence of cis and trans acting regulatory RNAs on a single molecule. Also, we highlight data showing that a key RNA chaperone in Enterobacteriaceae, Hfq, does not fulfill the same role in Gram-positive Firmicutes .