Advanced Sensing of Antibiotics with Magnetic Gold Nanocomposite: Electrochemical Detection of Chloramphenicol. Issue 40 (16th August 2016)

• Record Type: Journal Article
• Authors: Jakubec, Petr; Urbanová, Veronika; Medříková, Zdenka; Zbořil, Radek
• Is Part Of: Chemistry. Volume 22:Issue 40(2016)
• Page Start: 14279
• Page End: 14284
• Publication Date: 2016-08-16
• Subjects: antibiotics -- chloramphenicol -- electrochemistry -- gold nanoparticles -- magnetite; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201602434
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: The sensing and accurate determination of antibiotics in various environments represents a big challenge, mainly owing to their widespread use in medicine, veterinary practice, and other fields. Therefore, a new, simple electrochemical sensor for the detection of antibiotic chloramphenicol (CAP) has been developed in this work. The amplification strategy of the sensor is based on the application of magnetite nanostructures stabilized with carboxymethyl cellulose (Fe3 O4 ‐CMC) and decorated with nanometer‐sized Au nanoparticles (NPs) (Fe3 O4 ‐CMC@Au). In this case, CMC serves as a stabilizing agent, preventing the aggregation of Fe3 O4 NPs, and hence, enabling the kinetic barrier for electron transport to be overcome, and the Au NPs serve as an electron‐conducting tunnel for better electron transport. As a proof of concept, the developed nanosensor is used for the detection of CAP in human urine samples, giving a recovery value of around 97 %, which indicates the high accuracy of the as‐prepared nanosensor. Abstract : Sensing and sensitivity : The preparation of a novel electrochemical sensor for the determination of antibiotic chloramphenicol, based on the application of magnetite nanostructures stabilized with carboxymethyl cellulose (Fe3 O4 ‐CMC) and decorated with nanometer‐sized gold nanoparticles (Fe3 O4 ‐CMC@Au) is reported (see figure). The sensor described here has many attractive features such as simplicity, rapidity, low cost, and no requirement for a specific label.