All for one and FOSL1 for all: FOSL1 at the crossroads of lung and pancreatic cancer driven by mutant KRAS. (4th May 2017)
- Record Type:
- Journal Article
- Title:
- All for one and FOSL1 for all: FOSL1 at the crossroads of lung and pancreatic cancer driven by mutant KRAS. (4th May 2017)
- Main Title:
- All for one and FOSL1 for all: FOSL1 at the crossroads of lung and pancreatic cancer driven by mutant KRAS
- Authors:
- Vallejo, Adrian
Valencia, Karmele
Vicent, Silvestre - Abstract:
- ABSTRACT: KRAS proto-oncogene, GTPase ( KRAS ) remains refractory to current therapies. We devised an integrative cross-tumor approach to expose common core elements up-regulated in mutant KRAS cancers that could provide new treatment opportunities. This approach identified FOSL1 ( Fos-like antigen 1 ) as a clinically and functionally relevant gene in mutant KRAS -driven lung and pancreatic cancers, and unveiled downstream transcriptional targets amenable to pharmacological inhibition
- Is Part Of:
- Molecular & cellular oncology. Volume 4:Number 3(2017)
- Journal:
- Molecular & cellular oncology
- Issue:
- Volume 4:Number 3(2017)
- Issue Display:
- Volume 4, Issue 3 (2017)
- Year:
- 2017
- Volume:
- 4
- Issue:
- 3
- Issue Sort Value:
- 2017-0004-0003-0000
- Page Start:
- Page End:
- Publication Date:
- 2017-05-04
- Subjects:
- FOSL1 -- gene signature -- KRAS oncogene -- lung cancer -- mouse genetics -- pancreatic cancer -- pharmacological inhibitors
Tumors -- Periodicals
Neoplasms
Periodicals
616.99 - Journal URLs:
- http://www.tandfonline.com/loi/kmco20#.VyIIeFL2aic ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/23723556.2017.1314239 ↗
- Languages:
- English
- ISSNs:
- 2372-3556
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 8045.xml