Autophagic degradation of focal adhesions underlies metastatic cancer dissemination. (4th March 2017)

• Record Type: Journal Article
• Authors: Sharifi, Marina N.; Mowers, Erin E.; Macleod, Kay F.
• Is Part Of: Molecular & cellular oncology. Volume 4:Number 2(2017)
• Publication Date: 2017-03-04
• Subjects: Autophagy -- cell motility -- metastasis -- paxillin -- Src; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2016.1198299
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Autophagy inhibition is being evaluated as a novel therapeutic strategy in multiple tumor types, but little is known about its implications for metastatic dissemination. We recently reported that autophagic degradation of paxillin through direct interaction with the autophagy protein LC3B is required for focal adhesion disassembly, Src-stimulated tumor cell motility, and metastasis.