Novel mechanism of PCNA control through acetylation of its sliding surface. (4th March 2017)

• Record Type: Journal Article
• Authors: Billon, Pierre; Côté, Jacques
• Is Part Of: Molecular & cellular oncology. Volume 4:Number 2(2017)
• Publication Date: 2017-03-04
• Subjects: Cancer mutations -- DNA damage -- DNA polymerases -- DNA replication -- lysine acetylation -- PCNA -- sliding surface; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2017.1279724
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Recent findings revealed a new unexpected regulatory mechanism that controls the proliferating cell nuclear antigen (PCNA). Multiple positively-charged lysine residues located on the ring inner surface are neutralized by acetylation and required for cellular resistance to Desoxyribonucleic acid (DNA) damage. Here, we summarize the key observations, discuss implications, and perspectives linked to cancer, as well as challenges for future work.