Relevance of epithelial-to-pericyte transition in cancer. (2nd January 2017)

• Record Type: Journal Article
• Authors: Shenoy, Anitha K.; Lu, Jianrong
• Is Part Of: Molecular & cellular oncology. Volume 4:Number 1(2017)
• Publication Date: 2017-01-02
• Subjects: Blood vessel -- EMT -- endothelial cell -- EPT -- metastasis -- N-cadherin -- PDGFR-β -- pericyte; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2016.1260672
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: The relevance of epithelial-to-mesenchymal transition (EMT) in cancer is still under debate. Recently, we reported that EMT bestows key pericyte properties on cancer cells and may thus represent epithelial-to-pericyte transition (EPT). Carcinoma cells undergo EPT to stabilize blood vessels and fuel primary tumor growth. Association of EPT cancer cells with vascular niches may also promote resistance to therapy.