WRNIP1: A new guardian of genome integrity at stalled replication forks. (2nd September 2016)

• Record Type: Journal Article
• Authors: Leuzzi, Giuseppe; Marabitti, Veronica; Pichierri, Pietro; Franchitto, Annapaola
• Is Part Of: Molecular & cellular oncology. Volume 3:Number 5(2016)
• Publication Date: 2016-09-02
• Subjects: Genome instability -- replication fork stalling -- replication stress -- WRNIP1; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2016.1215777
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Failure to protect and/or restart stalled replication forks contributes to genomic instability. Radiation-sensitive 51 (RAD51) recombinase defends stalled forks from nucleolytic attack, which otherwise can threaten their integrity. Recently, we have uncovered a novel and key function of Werner helicase interacting protein 1 (WRNIP1) as a fork-protective factor working in conjunction with RAD51 in response to replication stress.