Vesicular trafficking regulators are new players in breast cancer progression: Role of TOM1L1 in ERBB2-dependent invasion. (3rd July 2016)

• Record Type: Journal Article
• Authors: Chevalier, Clément; Roche, Serge; Bénistant, Christine
• Is Part Of: Molecular & cellular oncology. Volume 3:Number 4(2016)
• Publication Date: 2016-07-03
• Subjects: Breast cancer -- metastasis -- tumor cell signaling -- tyrosine kinase -- vesicular trafficking; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2016.1182241
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2) amplification is associated with invasive breast cancer. We discovered that TOM1L1 (target of myb1-like 1) and ERBB2 co-amplification defines a novel mechanism involved in breast cancer metastatic progression. Upregulation of the vesicular trafficking protein TOM1L1 enhances plasma membrane delivery of membrane-type 1 matrix metalloprotease (MT1-MMP) for efficient extracellular matrix degradation and tumor cell dissemination.