A link between TP53 polymorphisms and metabolism. (3rd July 2016)

• Record Type: Journal Article
• Authors: Kung, Che-Pei; Basu, Subhasree; Murphy, Maureen E.
• Is Part Of: Molecular & cellular oncology. Volume 3:Number 4(2016)
• Publication Date: 2016-07-03
• Subjects: Diabetes -- inflammation -- lipid metabolism -- Npc1l1 -- obesity -- p53 polymorphism -- Tnf; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2016.1173769
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Besides being a critical tumor suppressor, the TP53 gene also plays a role in metabolism and recent studies in humans have implicated the codon 72 polymorphism of TP53 in this role. Using a humanized knock-in mouse model for these TP53 variants, we show that this polymorphism has a significant impact on the metabolic response to a high-fat diet.