NBR2: A former junk gene emerges as a key player in tumor suppression. (3rd July 2016)

• Record Type: Journal Article
• Authors: Xiao, Zhen-Dong; Liu, Xiaowen; Zhuang, Li; Gan, Boyi
• Is Part Of: Molecular & cellular oncology. Volume 3:Number 4(2016)
• Publication Date: 2016-07-03
• Subjects: AMPK -- BRCA1 -- energy stress response -- lncRNA -- NBR2 -- tumor suppression; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2016.1187322
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: NBR2 (neighbor of BRCA1 gene 2 ) is a non–protein coding gene that resides adjacent to tumor suppressor gene BRCA1, but its role in cancer biology has remained unknown. Our recent study showed that NBR2 encodes a long non-coding RNA and suppresses tumor development through regulation of adenosine monophosphate–activated protein kinase (AMPK) activation.