A metabolic link between the urea cycle and cancer cell proliferation. (3rd March 2016)
- Record Type:
- Journal Article
- Title:
- A metabolic link between the urea cycle and cancer cell proliferation. (3rd March 2016)
- Main Title:
- A metabolic link between the urea cycle and cancer cell proliferation
- Authors:
- Nagamani, Sandesh C.S.
Erez, Ayelet - Abstract:
- ABSTRACT: Clinical observations in citrullinemia type I, an inborn error of metabolism, led us to explore the benefits of somatic ASS1 silencing in cancer. We found that downregulation of ASS1 results in preferential utilization of its substrate, aspartate, for pyrimidine synthesis to support cell proliferation. Reducing aspartate availability for pyrimidine synthesis restricted cancerous proliferation.
- Is Part Of:
- Molecular & cellular oncology. Volume 3:Number 2(2016)
- Journal:
- Molecular & cellular oncology
- Issue:
- Volume 3:Number 2(2016)
- Issue Display:
- Volume 3, Issue 2 (2016)
- Year:
- 2016
- Volume:
- 3
- Issue:
- 2
- Issue Sort Value:
- 2016-0003-0002-0000
- Page Start:
- Page End:
- Publication Date:
- 2016-03-03
- Subjects:
- Aspartate -- argininosuccinate synthase -- cancer metabolism -- urea cycle -- pyrimidine synthesis
Tumors -- Periodicals
Neoplasms
Periodicals
616.99 - Journal URLs:
- http://www.tandfonline.com/loi/kmco20#.VyIIeFL2aic ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/23723556.2015.1127314 ↗
- Languages:
- English
- ISSNs:
- 2372-3556
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 8049.xml